TRPM2

From Wikipedia, the free encyclopedia

Transient receptor potential cation channel, subfamily M, member 2

Identifiers

TRPM2; EREG1; KNP3; LTRPC2; MGC133383; NUDT9H; NUDT9L1; TRPC7

External IDs

OMIM: 603749 MGI: 1351901 HomoloGene: 20709

Gene ontology
Molecular Function:	• ion channel activity • calcium channel activity • sodium channel activity • calcium ion binding • hydrolase activity • sodium ion binding • ADP-ribose diphosphatase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• ion transport • sodium ion transport • calcium ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001001188 (mRNA)
NP_001001188 (protein)

NM_138301 (mRNA)
NP_612174 (protein)

Location

Chr 21: 44.59 - 44.69 Mb

Chr 10: 77.31 - 77.37 Mb

Pubmed search

[1]

[2]

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a human gene.

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

TRPM

[edit] References

^ Entrez Gene: TRPM2 transient receptor potential cation channel, subfamily M, member 2.

[edit] Further reading

Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427-50. doi:10.1124/pr.57.4.6. PMID 16382100.
Eisfeld J, Lückhoff A (2007). "TRPM2.". Handb Exp Pharmacol (179): 237-52. doi:10.1007/978-3-540-34891-7_14. PMID 17217061.

[edit] External links

MeSH TRPM2+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel