Tropomyosin kinase

From Wikipedia, the free encyclopedia

In enzymology, a tropomyosin kinase (EC 2.7.11.28) is an enzyme that catalyzes the chemical reaction

ATP + tropomyosin ADP + O-phosphotropomyosin

Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.

[edit] References

• IUBMB entry for 2.7.11.28
• BRENDA references for 2.7.11.28 (Recommended.)
• PubMed references for 2.7.11.28
• PubMed Central references for 2.7.11.28
• Google Scholar references for 2.7.11.28
• deBelle I, Mak AS (1987). "Isolation and characterization of tropomyosin kinase from chicken embryo". Biochim. Biophys. Acta. 925: 17–26. PMID 3593768. 
• Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259: 5555–60. PMID 6325440. 
• Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues". Biochemistry. 27: 4506–12. doi:10.1021/bi00412a043. PMID 3166994. 

[edit] External links

The CAS registry number for this enzyme class is 90804-56-1.

• IUBMB entry for 2.7.11.28

• KEGG entry for 2.7.11.28

• BRENDA entry for 2.7.11.28

• NiceZyme view of 2.7.11.28

• EC2PDB: PDB structures for 2.7.11.28

• PRIAM entry for 2.7.11.28

• PUMA2 entry for 2.7.11.28

• IntEnz: Integrated Enzyme entry for 2.7.11.28

• MetaCyc entry for 2.7.11.28

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050359: tropomyosin kinase

• AMIGO entry for GO code 0050359: tropomyosin kinase