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Tropheryma whipplei is a bacterium and the causative organism of Whipple's disease.[1] While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[1] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case,[2] but no name was given to the organism until 1991 when the name Tropheryma whippelii was proposed after sections of the bacterial genome were sequenced.[3] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.[1]
[edit] Pathogenesis
- See Whipple's disease
[edit] References
- ^ a b c {La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D (2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus" (abstract page). Int J Syst Evol Microbiol 51 (Pt 4): 1471–9. PMID 11491348.
- ^ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.
- ^ Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. PMID 1377787.
