tRNA sulfurtransferase

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In enzymology, a tRNA sulfurtransferase (EC 2.8.1.4) is an enzyme that catalyzes the chemical reaction

L-cysteine + 'activated' tRNA $\rightleftharpoons$ L-serine + tRNA containing a thionucleotide

Thus, the two substrates of this enzyme are L-cysteine and 'activated' tRNA, whereas its two products are L-serine and tRNA containing a thionucleotide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is L-cysteine:tRNA sulfurtransferase. Other names in common use include transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, and transfer RNA thiolase.

[edit] References

IUBMB entry for 2.8.1.4
BRENDA references for 2.8.1.4 (Recommended.)
PubMed references for 2.8.1.4
PubMed Central references for 2.8.1.4
Google Scholar references for 2.8.1.4
Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system". J. Biol. Chem. 246: 294–301. PMID 5541999.
Hayward RS, Weiss SB (1966). "RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts". Proc. Natl. Acad. Sci. U. S. A. 55: 1161–8. PMID 5334200.
Lipsett MN, Peterkofsky A (1966). "Enzymatic thiolation of E. coli sRNA". Proc. Natl. Acad. Sci. U. S. A. 55: 1169–74. PMID 5334201.
Wong TW, Weiss SB, Eliceiri GL, Bryant J (1970). "Ribonucleic acid sulfurtransferase from Bacillus subtilis W168 Sulfuration with beta-mercaptopyruvate and properties of the enzyme system". Biochemistry. 9: 2376–86. PMID 4987417.