tRNA isopentenyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a tRNA isopentenyltransferase (EC 2.5.1.8) is an enzyme that catalyzes the chemical reaction
- isopentenyl diphosphate + tRNA diphosphate + tRNA containing 6-isopentenyladenosine
Thus, the two substrates of this enzyme are isopentenyl diphosphate and tRNA, whereas its two products are diphosphate and tRNA containing 6-isopentenyladenosine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is isopentenyl-diphosphate:tRNA isopentenyltransferase. Other names in common use include transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl, transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid, and Delta2-isopentenyltransferase.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QGN.
[edit] References
- IUBMB entry for 2.5.1.8
- BRENDA references for 2.5.1.8 (Recommended.)
- PubMed references for 2.5.1.8
- PubMed Central references for 2.5.1.8
- Google Scholar references for 2.5.1.8
- Kline LK, Fittler F, Hall RH (1969). "N6-(delta-2-isopentenyl) adenosine. Biosynthesis in transfer ribonucleic acid in vitro". Biochemistry. 8: 4361–71. PMID 4311031.
- Rosenbaum N, Gefter ML (1972). "Delta 2 -isopentenylpyrophosphate: transfer ribonucleic acid 2 -isopentenyltransferase from Escherichia coli. Purification and properties of the enzyme". J. Biol. Chem. 247: 5675–80. PMID 4341485.
[edit] External links
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- The CAS registry number for this enzyme class is 37277-78-4.