tRNA cytidylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a tRNA cytidylyltransferase (EC 2.7.7.21) is an enzyme that catalyzes the chemical reaction

CTP + tRNAn $\rightleftharpoons$ diphosphate + tRNAn⁺1

Thus, the two substrates of this enzyme are CTP and tRNA(n), whereas its two products are diphosphate and tRNA(n+1).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:tRNA cytidylyltransferase. Other names in common use include tRNA CCA-pyrophosphorylase, tRNA-nucleotidyltransferase, transfer-RNA nucleotidyltransferase, transfer ribonucleic acid nucleotidyl transferase, CTP(ATP):tRNA nucleotidyltransferase, transfer ribonucleate adenylyltransferase, transfer RNA adenylyltransferase, transfer ribonucleate nucleotidyltransferase, ATP (CTP):tRNA nucleotidyltransferase, ribonucleic cytidylic cytidylic adenylic pyrophosphorylase, transfer ribonucleate nucleotidyltransferase, transfer ribonucleic adenylyl (cytidylyl) transferase, transfer ribonucleic-terminal trinucleotide nucleotidyltransferase, transfer ribonucleate cytidylyltransferase, ribonucleic cytidylyltransferase, -C-C-A pyrophosphorylase, ATP(CTP)-tRNA nucleotidyltransferase, tRNA adenylyl(cytidylyl)transferase, ATP(CTP):tRNA nucleotidyltransferase, tRNA adenylyltransferase, and ATP:tRNA adenylyltransferase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 2DR5, 2DR7, 2DR8, 2DR9, 2DRA, 2DRB, and 2DVI.

[edit] References

IUBMB entry for 2.7.7.21
BRENDA references for 2.7.7.21 (Recommended.)
PubMed references for 2.7.7.21
PubMed Central references for 2.7.7.21
Google Scholar references for 2.7.7.21
Best AN, Novelli GD (1971). "Studies with tRNA adenylyl(cytidylyl)transferase from Escherichia coli B. I. Purification and kinetic properties". Arch. Biochem. Biophys. 142: 527–38. doi:10.1016/0003-9861(71)90516-9. PMID 4927556.
Best AN, Novelli GD (1971). "Studies with tRNA adenylyl(cytidylyl)transferase from Escherichia coli B. II. Regulation of AMP and CMP incorporation into tRNApCpC and tRNApC". Arch. Biochem. Biophys. 142: 539–47. doi:10.1016/0003-9861(71)90517-0. PMID 4927557.
Deutscher M (1972). "Synthesis and functions of the -C-C-A terminus of transfer RNA". Prog. Nucleic Acid Res. Mol. Biol. 13: 51–92.
Edmonds M (1965). "A cytidine triphosphate polymerase from thymus nuclei. 1 Purification and properties of the enzyme and its polynucleotide primer". J. Biol. Chem. 240: 4621–8. PMID 5846983.