tRNA-uridine aminocarboxypropyltransferase

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In enzymology, a tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA uridine 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and tRNA uridine, whereas its two products are 5'-methylthioadenosine and tRNA 3-(3-amino-3-carboxypropyl)-uridine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase.

[edit] References

• IUBMB entry for 2.5.1.25
• BRENDA references for 2.5.1.25 (Recommended.)
• PubMed references for 2.5.1.25
• PubMed Central references for 2.5.1.25
• Google Scholar references for 2.5.1.25
• Nishimura S, Taya Y, Kuchino Y, Oashi Z (1974). "Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine". Biochem. Biophys. Res. Commun. 57: 702–8. PMID 4597321. 

[edit] External links

• IUBMB entry for 2.5.1.25

• KEGG entry for 2.5.1.25

• BRENDA entry for 2.5.1.25

• NiceZyme view of 2.5.1.25

• EC2PDB: PDB structures for 2.5.1.25

• PRIAM entry for 2.5.1.25

• PUMA2 entry for 2.5.1.25

• IntEnz: Integrated Enzyme entry for 2.5.1.25

• MetaCyc entry for 2.5.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016432: tRNA-uridine aminocarboxypropyltransferase

• AMIGO entry for GO code 0016432: tRNA-uridine aminocarboxypropyltransferase