TRMU

From Wikipedia, the free encyclopedia

TRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

Identifiers

TRMU; TRNT1; TRMT1; MGC99627; MTO2; MTU1; TRMT

External IDs

OMIM: 610230 MGI: 1919276 HomoloGene: 5589

Gene ontology
Molecular Function:	• tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity • methyltransferase activity • transferase activity
Cellular Component:	• cytoplasm • mitochondrion
Biological Process:	• tRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018006 (mRNA)
NP_060476 (protein)

NM_028063 (mRNA)
NP_082339 (protein)

Location

Chr 22: 45.11 - 45.13 Mb

Chr 15: 85.71 - 85.73 Mb

Pubmed search

[1]

[2]

TRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, also known as TRMU, is a human gene.^[1]

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase.

[edit] Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yan Q, Guan MX (2004). "Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase.". Biochim. Biophys. Acta 1676 (2): 119–26. PMID 14746906.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Umeda N, Suzuki T, Yukawa M, et al. (2005). "Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.". J. Biol. Chem. 280 (2): 1613–24. doi:10.1074/jbc.M409306200. PMID 15509579.
Yan Q, Li X, Faye G, Guan MX (2005). "Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA.". J. Biol. Chem. 280 (32): 29151–7. doi:10.1074/jbc.M504247200. PMID 15944150.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Yan Q, Bykhovskaya Y, Li R, et al. (2006). "Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations.". Biochem. Biophys. Res. Commun. 342 (4): 1130–6. doi:10.1016/j.bbrc.2006.02.078. PMID 16513084.
Guan MX, Yan Q, Li X, et al. (2006). "Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.". Am. J. Hum. Genet. 79 (2): 291–302. doi:10.1086/506389. PMID 16826519.