Trihydroxystilbene synthase

From Wikipedia, the free encyclopedia

In enzymology, a trihydroxystilbene synthase (EC 2.3.1.95) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO₂

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, 3,4',5-trihydroxy-stilbene, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include resveratrol synthase, and stilbene synthase. This enzyme participates in phenylpropanoid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Z1E and 1Z1F.

[edit] References

• IUBMB entry for 2.3.1.95
• BRENDA references for 2.3.1.95 (Recommended.)
• PubMed references for 2.3.1.95
• PubMed Central references for 2.3.1.95
• Google Scholar references for 2.3.1.95
• Schoppner A, Kindl H (1984). "Purification and properties of a stilbene synthase from induced cell suspension cultures of peanut". J. Biol. Chem. 259: 6806–11. PMID 6427224. 

[edit] External links

The CAS registry number for this enzyme class is 128449-70-7.

• IUBMB entry for 2.3.1.95

• KEGG entry for 2.3.1.95

• BRENDA entry for 2.3.1.95

• NiceZyme view of 2.3.1.95

• EC2PDB: PDB structures for 2.3.1.95

• PRIAM entry for 2.3.1.95

• PUMA2 entry for 2.3.1.95

• IntEnz: Integrated Enzyme entry for 2.3.1.95

• MetaCyc entry for 2.3.1.95

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050350: trihydroxystilbene synthase

• AMIGO entry for GO code 0050350: trihydroxystilbene synthase