Talk:Trimethoprim

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Correction suggested in Mechanism of Action: THF is a precursor to the nucleotide thymidine (not thymine, which is a base). Also, cells are not starved for bases required in DNA replication, but for deoxyribose nucleotide, specifically thymidine.

Correction to picture: sulfonamides inhibit dihydropteroate synthase, not reductase. Can someone change this please? Axl 13:19, 15 Nov 2004 (UTC)

You'd have to ask User:Techelf, who produced this. JFW | T@lk 14:22, 15 Nov 2004 (UTC)

Yep, thanks for pointing that out - I've corrected the error in the diagram. Techelf 06:15, 16 Nov 2004 (UTC)

Thanks for fixing it. :-) Axl 11:13, 19 Nov 2004 (UTC)

[edit] Confused about the "Mechanism of action" section

Should the sentence starting "Folic acid is an essential precursor in the de novo synthesis..." start with "Tetrahydrofolic acid..."  ??

If not, how is inhibition of tetrahydrofolic acid synthesis supposed to affect de novo synthesis of thymidine and uridine?

Or, if folic acid is an essential precursor of thymidine and uridine, the article doesn't make clear why inhibiting reduction of dihydrofolic acid to tetrahydrofolic acid inhibits tymidine and uridine synthesis.

Grant..

You're right, it was a bit unclear. Technically it was correct (since folate -> dihydrofolate -> tetrahydrofolate), but most people probably don't know that. I've clarified it in the article. -Techelf 08:55, 28 May 2006 (UTC)