TRIM6

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Tripartite motif-containing 6
Identifiers
Symbol(s) TRIM6; RNF89
External IDs OMIM: 607564 MGI: 2137352 HomoloGene: 14381
Orthologs
Human Mouse
Entrez 117854 94088


Refseq NM_001003818 (mRNA)
NP_001003818 (protein)		 NM_001013616 (mRNA)
NP_001013637 (protein)
Pubmed search [1] [2]

Tripartite motif-containing 6, also known as TRIM6, is a human gene.[1]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: TRIM6 tripartite motif-containing 6.

[edit] Further reading

  • Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members.". Virology 360 (2): 419-33. doi:10.1016/j.virol.2006.10.035. PMID 17156811. 
  • Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins.". Virology 353 (2): 396-409. doi:10.1016/j.virol.2006.05.035. PMID 16828831. 
  • Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.". J. Virol. 80 (13): 6198-206. doi:10.1128/JVI.00283-06. PMID 16775307. 
  • Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353-63. doi:10.1038/sj.emboj.7600994. PMID 16498413. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140-51. doi:10.1093/emboj/20.9.2140. PMID 11331580. 
  • Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.". Genomics 69 (1): 143-9. doi:10.1006/geno.2000.6318. PMID 11013086. 
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