TRIM55

From Wikipedia, the free encyclopedia

Tripartite motif-containing 55

Identifiers

TRIM55; MURF-2; RNF29

External IDs

OMIM: 606469 MGI: 3036269 HomoloGene: 13205

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus • microtubule
Biological Process:	• signal transduction

Orthologs

Human

Mouse

n/a

Refseq

NM_033058 (mRNA)
NP_149047 (protein)

XM_355438 (mRNA)
XP_355438 (protein)

Location

Chr 8: 67.2 - 67.25 Mb

Chr 3: 19.84 - 19.85 Mb

Pubmed search

[1]

[2]

Tripartite motif-containing 55, also known as TRIM55, is a human gene.^[1]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM55 tripartite motif-containing 55.

[edit] Further reading

Centner T, Yano J, Kimura E, et al. (2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.". J. Mol. Biol. 306 (4): 717-26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.". J. Cell Biol. 157 (1): 125-36. doi:10.1083/jcb.200108089. PMID 11927605.
Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein.". J. Cell. Sci. 115 (Pt 23): 4469-82. PMID 12414993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.". Nat. Methods 2 (1): 47-53. doi:10.1038/nmeth726. PMID 15782160.
Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover.". Science 308 (5728): 1599-603. doi:10.1126/science.1110463. PMID 15802564.
Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.". J. Mol. Biol. 350 (4): 713-22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462.