TRIM37

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Tripartite motif-containing 37
Identifiers
Symbol(s) TRIM37; KIAA0898; MUL; POB1; TEF3
External IDs OMIM: 605073 MGI: 2153072 HomoloGene: 9084
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4591 68729
Ensembl ENSG00000108395 ENSMUSG00000018548
Uniprot O94972 Q5SX31
Refseq NM_001005207 (mRNA)
NP_001005207 (protein)		 NM_197987 (mRNA)
NP_932104 (protein)
Location Chr 17: 54.43 - 54.54 Mb Chr 11: 86.94 - 87.04 Mb
Pubmed search [1] [2]

Tripartite motif-containing 37, also known as TRIM37, is a human gene.[1]

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: TRIM37 tripartite motif-containing 37.

[edit] Further reading

  • Avela K, Lipsanen-Nyman M, Perheentupa J, et al. (1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis.". Am. J. Hum. Genet. 60 (4): 896–902. PMID 9106536. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485. 
  • Avela K, Lipsanen-Nyman M, Idänheimo N, et al. (2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism.". Nat. Genet. 25 (3): 298–301. doi:10.1038/77053. PMID 10888877. 
  • Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055. 
  • Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580. 
  • Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND (2002). "Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis.". Mech. Dev. 108 (1-2): 221–5. PMID 11578880. 
  • Kallijärvi J, Avela K, Lipsanen-Nyman M, et al. (2002). "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder.". Am. J. Hum. Genet. 70 (5): 1215–28. PMID 11938494. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jagiello P, Hammans C, Wieczorek S, et al. (2003). "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity.". Hum. Mutat. 21 (6): 630–5. doi:10.1002/humu.10220. PMID 12754710. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Hämäläinen RH, Avela K, Lambert JA, et al. (2004). "Novel mutations in the TRIM37 gene in Mulibrey Nanism.". Hum. Mutat. 23 (5): 522. doi:10.1002/humu.9233. PMID 15108285. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kallijärvi J, Lahtinen U, Hämäläinen R, et al. (2005). "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.". Exp. Cell Res. 308 (1): 146–55. doi:10.1016/j.yexcr.2005.04.001. PMID 15885686. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Karlberg N, Jalanko H, Kallijärvi J, et al. (2006). "Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37.". Diabetes 54 (12): 3577–81. PMID 16306379. 
  • Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE (2006). "Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing.". Gene 366 (1): 180–8. doi:10.1016/j.gene.2005.08.008. PMID 16310976. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Hämäläinen RH, Mowat D, Gabbett MT, et al. (2007). "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism.". Clin. Genet. 70 (6): 473–9. doi:10.1111/j.1399-0004.2006.00700.x. PMID 17100991. 
  • Doğanc T, Yüksel Konuk BE, Alpan N, et al. (2007). "A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy.". Clin. Dysmorphol. 16 (3): 173–6. doi:10.1097/MCD.0b013e3280f6d00b. PMID 17551331. 
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