TRIM28

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Tripartite motif-containing 28
Identifiers
Symbol(s) TRIM28; KAP1; FLJ29029; RNF96; TF1B; TIF1B
External IDs OMIM: 601742 MGI: 109274 HomoloGene: 21175
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10155 21849
Ensembl ENSG00000130726 ENSMUSG00000005566
Uniprot Q13263 Q3UDN8
Refseq NM_005762 (mRNA)
NP_005753 (protein)		 NM_011588 (mRNA)
NP_035718 (protein)
Location Chr 19: 63.55 - 63.75 Mb Chr 7: 11.92 - 11.93 Mb
Pubmed search [1] [2]

Tripartite motif-containing 28, also known as TRIM28, is a human gene.

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: TRIM28 tripartite motif-containing 28.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Friedman JR, Fredericks WJ, Jensen DE, et al. (1996). "KAP-1, a novel corepressor for the highly conserved KRAB repression domain.". Genes Dev. 10 (16): 2067–78. PMID 8769649. 
  • Kim SS, Chen YM, O'Leary E, et al. (1997). "A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15299–304. PMID 8986806. 
  • Moosmann P, Georgiev O, Le Douarin B, et al. (1997). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.". Nucleic Acids Res. 24 (24): 4859–67. PMID 9016654. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Chang CJ, Chen YL, Lee SC (1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression.". Mol. Cell. Biol. 18 (10): 5880–7. PMID 9742105. 
  • Eng FC, Barsalou A, Akutsu N, et al. (1998). "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain.". J. Biol. Chem. 273 (43): 28371–7. PMID 9774463. 
  • Ryan RF, Schultz DC, Ayyanathan K, et al. (1999). "KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.". Mol. Cell. Biol. 19 (6): 4366–78. PMID 10330177. 
  • Agata Y, Matsuda E, Shimizu A (1999). "Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1).". J. Biol. Chem. 274 (23): 16412–22. PMID 10347202. 
  • Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMID 10562550. 
  • Peng H, Begg GE, Harper SL, et al. (2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain.". J. Biol. Chem. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030. 
  • Lechner MS, Begg GE, Speicher DW, Rauscher FJ (2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential.". Mol. Cell. Biol. 20 (17): 6449–65. PMID 10938122. 
  • Underhill C, Qutob MS, Yee SP, Torchia J (2001). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.". J. Biol. Chem. 275 (51): 40463–70. doi:10.1074/jbc.M007864200. PMID 11013263. 
  • Gebelein B, Urrutia R (2001). "Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein.". Mol. Cell. Biol. 21 (3): 928–39. doi:10.1128/MCB.21.3.928-939.2001. PMID 11154279. 
  • Capili AD, Schultz DC, RauscherIII FJ, Borden KL (2001). "Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.". EMBO J. 20 (1-2): 165–77. doi:10.1093/emboj/20.1.165. PMID 11226167. 
  • Schultz DC, Friedman JR, Rauscher FJ (2001). "Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.". Genes Dev. 15 (4): 428–43. doi:10.1101/gad.869501. PMID 11230151. 
  • Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580. 
  • Hsu SI, Yang CM, Sim KG, et al. (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMID 11331592. 
  • Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.". Mol. Cell 7 (4): 729–39. PMID 11336697. 
  • Rooney JW, Calame KL (2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937.". Genes Dev. 15 (22): 3023–38. doi:10.1101/gad.937201. PMID 11711437. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors