TRIM22

From Wikipedia, the free encyclopedia

Tripartite motif-containing 22

Identifiers

TRIM22; GPSTAF50; RNF94; STAF50

External IDs

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of transcription, DNA-dependent • immune response • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_006074 (mRNA)
NP_006065 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 5.67 - 5.69 Mb

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Pubmed search

[1]

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Tripartite motif-containing 22, also known as TRIM22, is a human gene.^[1]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.^[1]

According to researcher Stephen Barr, a molecular virologist in the Department of Medical Microbiology and Immunology, gene TRIM22 prevents the assembly of the HIV virus.^[2]

[edit] References

[edit] Further reading

Tissot C, Mechti N (1995). "Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression.". J. Biol. Chem. 270 (25): 14891–8. PMID 7797467.
Tissot C, Taviaux SA, Diriong S, Mechti N (1996). "Localization of Staf50, a member of the Ring finger family, to 11p15 by fluorescence in situ hybridization.". Genomics 34 (1): 151–3. doi:10.1006/geno.1996.0258. PMID 8661041.
Gongora C, Tissot C, Cerdan C, Mechti N (2001). "The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28.". J. Interferon Cytokine Res. 20 (11): 955–61. doi:10.1089/10799900050198390. PMID 11096452.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Obad S, Brunnström H, Vallon-Christersson J, et al. (2004). "Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.". Oncogene 23 (23): 4050–9. doi:10.1038/sj.onc.1207524. PMID 15064739.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Bouazzaoui A, Kreutz M, Eisert V, et al. (2007). "Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages.". Virology 356 (1-2): 79–94. doi:10.1016/j.virol.2006.07.025. PMID 16926043.