TRIM21

From Wikipedia, the free encyclopedia

Tripartite motif-containing 21

PDB rendering based on 2iwg.

Available structures: 2iwg

Identifiers

Symbol(s)

TRIM21; SSA; RNF81; RO52; SSA1

External IDs

OMIM: 109092 MGI: 106657 HomoloGene: 2365

Gene ontology
Molecular Function:	• DNA binding • RNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • cytoplasm • ribonucleoprotein complex

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003141 (mRNA)
NP_003132 (protein)

XM_991802 (mRNA)
XP_996896 (protein)

Location

Chr 11: 4.36 - 4.37 Mb

Chr 7: 102.43 - 102.44 Mb

Pubmed search

[1]

[2]

Tripartite motif-containing 21, also known as TRIM21, is a human gene.^[1]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM21 tripartite motif-containing 21.

[edit] Further reading

Jones SK (1992). "Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions.". Br. J. Dermatol. 126 (6): 546-53. PMID 1610705.
Itoh K, Itoh Y, Frank MB (1991). "Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.". J. Clin. Invest. 87 (1): 177-86. PMID 1985094.
Chan EK, Hamel JC, Buyon JP, Tan EM (1991). "Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.". J. Clin. Invest. 87 (1): 68-76. PMID 1985112.
Miyagawa S, Okada N, Inagaki Y, et al. (1988). "SSA/Ro antigen expression in simian virus 40-transformed human keratinocytes.". J. Invest. Dermatol. 90 (3): 342-5. PMID 2450143.
Chan EK, Di Donato F, Hamel JC, et al. (1995). "52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.". J. Exp. Med. 182 (4): 983-92. PMID 7561701.
Tsugu H, Horowitz R, Gibson N, Frank MB (1995). "The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1).". Genomics 24 (3): 541-8. doi:10.1006/geno.1994.1664. PMID 7713506.
Frank MB, McCubbin VR, Heldermon C (1995). "Expression and DNA binding of the human 52 kDa Ro/SSA autoantigen.". Biochem. J. 305 ( Pt 2): 359-62. PMID 7832745.
Frank MB, Itoh K, Fujisaku A, et al. (1993). "The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms.". Am. J. Hum. Genet. 52 (1): 183-91. PMID 8094596.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Keech CL, Gordon TP, McCluskey J (1996). "Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species.". Clin. Exp. Immunol. 104 (2): 255-63. PMID 8625517.
Igarashi T, Itoh Y, Fukunaga Y, Yamamoto M (1996). "Stress-induced cell surface expression and antigenic alteration of the Ro/SSA autoantigen.". Autoimmunity 22 (1): 33-42. PMID 8882420.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Bepler G, O'briant KC, Kim YC, et al. (1999). "A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region.". Genomics 55 (2): 164-75. doi:10.1006/geno.1998.5659. PMID 9933563.
Tseng CE, Miranda E, Di Donato F, et al. (1999). "mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure.". Pediatr. Res. 45 (2): 260-9. PMID 10022600.
Fabini G, Rutjes SA, Zimmermann C, et al. (2000). "Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins.". Eur. J. Biochem. 267 (9): 2778-89. PMID 10785401.
Kurien BT, Chambers TL, Thomas PY, et al. (2001). "Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA.". Scand. J. Immunol. 53 (3): 268-76. PMID 11251884.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140-51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
Di Donato F, Chan EK, Askanase AD, et al. (2001). "Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function.". Int. J. Biochem. Cell Biol. 33 (9): 924-34. PMID 11461834.
Fukuda-Kamitani T, Kamitani T (2002). "Ubiquitination of Ro52 autoantigen.". Biochem. Biophys. Res. Commun. 295 (4): 774-8. PMID 12127959.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.