TRIM16

From Wikipedia, the free encyclopedia

Tripartite motif-containing 16

Identifiers

External IDs

OMIM: 609505 MGI: 2137356 HomoloGene: 4726

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • cytoplasm

Orthologs

Human

Mouse

Entrez

10626

94092

Refseq

XM_001129610 (mRNA)
XP_001129610 (protein)

NM_053169 (mRNA)
NP_444399 (protein)

Pubmed search

[1]

[2]

Tripartite motif-containing 16, also known as TRIM16, is a human gene.^[1]

This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM16 tripartite motif-containing 16.

[edit] Further reading

Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant.". Mol. Endocrinol. 12 (11): 1733–48. PMID 9817599.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation.". J. Biol. Chem. 277 (23): 20740–9. doi:10.1074/jbc.M111233200. PMID 11919186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion.". Cell Death Differ. 13 (11): 1938–49. doi:10.1038/sj.cdd.4401896. PMID 16575408.
Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal.". J. Biol. Chem. 281 (26): 18246–56. doi:10.1074/jbc.M600879200. PMID 16636064.