TRIM15

From Wikipedia, the free encyclopedia

Tripartite motif-containing 15

Identifiers

TRIM15; RNF93; ZNF178; ZNFB7

External IDs

MGI: 1916347 HomoloGene: 23819

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular
Biological Process:	• mesodermal cell fate determination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_033229 (mRNA)
NP_150232 (protein)

NM_001024134 (mRNA)
NP_001019305 (protein)

Location

Chr c6_QBL: 30.26 - 30.27 Mb

Chr 17: 36.47 - 36.48 Mb

Pubmed search

[1]

[2]

Tripartite motif-containing 15, also known as TRIM15, is a human gene.^[1]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM15 tripartite motif-containing 15.

[edit] Further reading

Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.". Genetics 173 (3): 1555-70. doi:10.1534/genetics.106.057034. PMID 16702430.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140-51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.". Mol. Cell. Biol. 19 (5): 3808-15. PMID 10207104.
Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region.". Genomics 36 (1): 70-85. PMID 8812418.
Goei VL, Parimoo S, Capossela A, et al. (1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection.". Am. J. Hum. Genet. 54 (2): 244-51. PMID 8304341.