TRIM11

From Wikipedia, the free encyclopedia

Tripartite motif-containing 11

Identifiers

TRIM11; BIA1; RNF92

External IDs

OMIM: 607868 MGI: 2137355 HomoloGene: 14225

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• ubiquitin cycle

Orthologs

Human

Mouse

Refseq

NM_145214 (mRNA)
NP_660215 (protein)

NM_053168 (mRNA)
NP_444398 (protein)

Location

Chr 1: 226.65 - 226.66 Mb

Chr 11: 58.79 - 58.81 Mb

Pubmed search

[1]

[2]

Tripartite motif-containing 11, also known as TRIM11, is a human gene.^[1]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM11 tripartite motif-containing 11.

[edit] Further reading

Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system.". FEBS Lett. 580 (20): 4784-92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMID 16098226.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Niikura T, Hashimoto Y, Tajima H, et al. (2003). "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.". Eur. J. Neurosci. 17 (6): 1150-8. PMID 12670303.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140-51. doi:10.1093/emboj/20.9.2140. PMID 11331580.