TRIB3

From Wikipedia, the free encyclopedia

Tribbles homolog 3 (Drosophila)

Identifiers

TRIB3; TRB3; C20orf97; NIPK; SINK; SKIP3

External IDs

OMIM: 607898 MGI: 1345675 HomoloGene: 10902

Gene ontology
Molecular Function:	• transcription corepressor activity • protein kinase activity • protein kinase inhibitor activity • protein binding • ATP binding • protein kinase binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • negative regulation of protein kinase activity • apoptosis • regulation of MAPK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021158 (mRNA)
NP_066981 (protein)

NM_144554 (mRNA)
NP_653137 (protein)

Location

Chr 20: 0.31 - 0.33 Mb

Chr 2: 152.03 - 152.03 Mb

Pubmed search

[1]

[2]

Tribbles homolog 3 (Drosophila), also known as TRIB3, is a human gene.^[1]

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila).

[edit] Further reading

Hegedus Z, Czibula A, Kiss-Toth E (2006). "Tribbles: novel regulators of cell function; evolutionary aspects.". Cell. Mol. Life Sci. 63 (14): 1632-41. doi:10.1007/s00018-006-6007-9. PMID 16715410.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wu M, Xu LG, Zhai Z, Shu HB (2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.". J. Biol. Chem. 278 (29): 27072-9. doi:10.1074/jbc.M209814200. PMID 12736262.
Bowers AJ, Scully S, Boylan JF (2003). "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.". Oncogene 22 (18): 2823-35. doi:10.1038/sj.onc.1206367. PMID 12743605.
Du K, Herzig S, Kulkarni RN, Montminy M (2003). "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.". Science 300 (5625): 1574-7. doi:10.1126/science.1079817. PMID 12791994.
Huang J, Teng L, Liu T, et al. (2003). "Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription.". Biochem. Biophys. Res. Commun. 309 (4): 774-8. PMID 13679039.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kiss-Toth E, Bagstaff SM, Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.". J. Biol. Chem. 279 (41): 42703-8. doi:10.1074/jbc.M407732200. PMID 15299019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ohoka N, Yoshii S, Hattori T, et al. (2005). "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.". EMBO J. 24 (6): 1243-55. doi:10.1038/sj.emboj.7600596. PMID 15775988.
Ord D, Ord T (2005). "Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.". Biochem. Biophys. Res. Commun. 330 (1): 210-8. doi:10.1016/j.bbrc.2005.02.149. PMID 15781252.
Prudente S, Hribal ML, Flex E, et al. (2005). "The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.". Diabetes 54 (9): 2807-11. PMID 16123373.
Schwarzer R, Dames S, Tondera D, et al. (2006). "TRB3 is a PI 3-kinase dependent indicator for nutrient starvation.". Cell. Signal. 18 (6): 899-909. doi:10.1016/j.cellsig.2005.08.002. PMID 16129579.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Matsushima R, Harada N, Webster NJ, et al. (2006). "Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity.". J. Biol. Chem. 281 (40): 29719-29. doi:10.1074/jbc.M511636200. PMID 16887816.
Koh HJ, Arnolds DE, Fujii N, et al. (2007). "Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.". Mol. Cell. Biol. 26 (22): 8217-27. doi:10.1128/MCB.00979-06. PMID 16966378.