TRIB1

From Wikipedia, the free encyclopedia

Tribbles homolog 1 (Drosophila)

Identifiers

TRIB1; GIG2; C8FW; SKIP1

External IDs

Gene ontology
Molecular Function:	• protein kinase activity • protein kinase inhibitor activity • protein binding • ATP binding
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation • cell proliferation • regulation of MAPK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025195 (mRNA)
NP_079471 (protein)

NM_144549 (mRNA)
NP_653132 (protein)

Location

Chr 8: 126.51 - 126.52 Mb

Chr 15: 59.48 - 59.49 Mb

Pubmed search

[1]

[2]

Tribbles homolog 1 (Drosophila), also known as TRIB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRIB1 tribbles homolog 1 (Drosophila).

[edit] Further reading

Hegedus Z, Czibula A, Kiss-Toth E (2006). "Tribbles: novel regulators of cell function; evolutionary aspects.". Cell. Mol. Life Sci. 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMID 16715410.
Wilkin F, Suarez-Huerta N, Robaye B, et al. (1997). "Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.". Eur. J. Biochem. 248 (3): 660–8. PMID 9342215.
Tang K, Finley RL, Nie D, Honn KV (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.". Biochemistry 39 (12): 3185–91. PMID 10727209.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wu M, Xu LG, Zhai Z, Shu HB (2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.". J. Biol. Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kiss-Toth E, Bagstaff SM, Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.". J. Biol. Chem. 279 (41): 42703–8. doi:10.1074/jbc.M407732200. PMID 15299019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Xu C, Zhang J, Huang X, et al. (2006). "Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP.". J. Biol. Chem. 281 (23): 15900–8. doi:10.1074/jbc.M511155200. PMID 16595688.
Sung HY, Guan H, Czibula A, et al. (2007). "Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.". J. Biol. Chem. 282 (25): 18379–87. doi:10.1074/jbc.M610792200. PMID 17452330.