Tremelimumab

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Tremelimumab?
Therapeutic monoclonal antibody
Source	Human
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Tremelimumab (anti-CTLA4 human monoclonal antibody CP-675,206) (formerly ticilimumab) is a fully human monoclonal antibody produced by Pfizer. It binds to the CTLA-4 molecule, which is expressed on the surface of activated T lymphocytes. Tremelimumab binds to CTLA4 and blocks the binding of the antigen-presenting cell ligands B7-1 and B7-2 to CTLA4, resulting in inhibition of B7-CTLA4-mediated downregulation of T-cell activation; subsequently, B7-1 or B7-2 may interact with another T-cell surface receptor protein, CD28, resulting in a B7-CD28-mediated T-cell activation unopposed by B7-CTLA4-mediated inhibition. Tremelimumab is thought to stimulate patients’ immune systems to attack their tumors. Tremelimumab has been shown to induce durable tumor responses in patients with metastatic melanoma in Phase 1 and Phase 2 clinical studies. See Reuben JM et al., Biologic and immunomodulatory events after CTLA-4 blockade with tremelimumab in patients with advanced malignant melanoma. Cancer. 2006 Jun 1;106 (11):2437-44.

As of June 2007 there are two fully human anti CTLA-4 [1] monoclonal antibodies in advanced clinical trials. Tremelimumab (from Pfizer) is an IgG2, and Ipilimumab (from Medarex and Bristol-Myers Squibb). On April 2, 2008, Pfizer announced that it has discontinued a Phase III clinical trial (A3671009), tremelimumab in patients with advanced melanoma, after the review of interim data showed that the trial would not demonstrate superiority to standard chemotherapy.^[1]

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v • d • e Human monoclonal antibodies ("-u-") "-limu-" (immune system) immunosuppression: Adalimumab, Atorolimumab, Gantenerumab, Golimumab, Lerdelimumab, Metelimumab, Morolimumab, Ziralimumab immune activation: Ipilimumab, Tremelimumab other: Bertilimumab "-kinu-" (interleukin as target) Canakinumab "-tumu-" (cancer immunotherapy) Adecatumumab, Anetumumab, Belimumab, Duntumumab, Iratumumab, Lexatumumab, Lucatumumab, Mapatumumab, Ofatumumab, Panitumumab, Pritumumab, Votumumab, Zalutumumab, Zanolimumab "-osu-" (bone) Denosumab "-mulu-" (musculoskeletal) Durimulumab, Durmulumab, Stamulumab "-fungu-" (fungal) Efungumab "-viru-" (viral) Exbivirumab, Libivirumab, Regavirumab, Sevirumab, Tuvirumab "-bacu-" (bacterial) Nebacumab, Raxibacumab