Trefoil factor 3

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Trefoil factor 3 (intestinal)
PDB rendering based on 1e9t.
Available structures: 1e9t, 1pe3
Identifiers
Symbol(s) TFF3; HITF; ITF; TFI; hP1.B
External IDs OMIM: 600633 MGI: 104638 HomoloGene: 2427
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7033 21786
Ensembl ENSG00000160180 ENSMUSG00000024029
Uniprot Q07654 Q62395
Refseq NM_003226 (mRNA)
NP_003217 (protein)		 NM_011575 (mRNA)
NP_035705 (protein)
Location Chr 21: 42.6 - 42.61 Mb Chr 17: 30.85 - 30.86 Mb
Pubmed search [1] [2]

Trefoil factor 3 (intestinal), also known as TFF3, is a human gene.[1]

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[1]

[edit] References

  1. ^ a b Entrez Gene: TFF3 trefoil factor 3 (intestinal).

[edit] Further reading

  • Hoffmann W, Jagla W, Wiede A (2001). "Molecular medicine of TFF-peptides: from gut to brain.". Histol. Histopathol. 16 (1): 319-34. PMID 11193208. 
  • Hoffmann W, Jagla W (2002). "Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain.". Int. Rev. Cytol. 213: 147-81. PMID 11837892. 
  • Langer G, Jagla W, Behrens-Baumann W, et al. (2003). "Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells.". Adv. Exp. Med. Biol. 506 (Pt A): 313-6. PMID 12613926. 
  • Seib T, Dooley S, Welter C (1995). "Characterization of the genomic structure and the promoter region of the human intestinal trefoil factor.". Biochem. Biophys. Res. Commun. 214 (1): 195-9. doi:10.1006/bbrc.1995.2274. PMID 7669039. 
  • Thim L, Wöldike HF, Nielsen PF, et al. (1995). "Characterization of human and rat intestinal trefoil factor produced in yeast.". Biochemistry 34 (14): 4757-64. PMID 7718582. 
  • Hauser F, Poulsom R, Chinery R, et al. (1993). "hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus.". Proc. Natl. Acad. Sci. U.S.A. 90 (15): 6961-5. PMID 8346203. 
  • Podolsky DK, Lynch-Devaney K, Stow JL, et al. (1993). "Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion.". J. Biol. Chem. 268 (9): 6694-702. PMID 8454642. 
  • Schmitt H, Wundrack I, Beck S, et al. (1996). "A third P-domain peptide gene (TFF3), human intestinal trefoil factor, maps to 21q22.3.". Cytogenet. Cell Genet. 72 (4): 299-302. PMID 8641134. 
  • Chinery R, Williamson J, Poulsom R (1997). "The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family.". Genomics 32 (2): 281-4. doi:10.1006/geno.1996.0117. PMID 8833157. 
  • Probst JC, Zetzsche T, Weber M, et al. (1997). "Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide.". FASEB J. 10 (13): 1518-23. PMID 8940297. 
  • Gött P, Beck S, Machado JC, et al. (1997). "Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression.". Eur. J. Hum. Genet. 4 (6): 308-15. PMID 9043862. 
  • Seib T, Blin N, Hilgert K, et al. (1997). "The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.". Genomics 40 (1): 200-2. doi:10.1006/geno.1996.4511. PMID 9070946. 
  • Tan XD, Liu QP, Hsueh W, et al. (1999). "Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: priming and enhancing effects of mucin.". Biochem. J. 338 ( Pt 3): 745-51. PMID 10051448. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953. 
  • Berry A, Scott HS, Kudoh J, et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.". Genomics 68 (1): 22-9. doi:10.1006/geno.2000.6253. PMID 10950923. 
  • Wiede A, Hinz M, Canzler E, et al. (2001). "Synthesis and localization of the mucin-associated TFF-peptides in the human uterus.". Cell Tissue Res. 303 (1): 109-15. PMID 11235998. 
  • Yamachika T, Werther JL, Bodian C, et al. (2002). "Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma.". Clin. Cancer Res. 8 (5): 1092-9. PMID 12006524. 
  • Kimura Y, Leung PS, Kenny TP, et al. (2002). "Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis.". Hepatology 36 (5): 1227-35. doi:10.1053/jhep.2002.36157. PMID 12395334. 
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