TREX1

From Wikipedia, the free encyclopedia

Three prime repair exonuclease 1

Identifiers

TREX1; AGS1; ATRIP; DKFZp434J0310; DRN3; FLJ12343

External IDs

OMIM: 606605 MGI: 1925349 HomoloGene: 15601

Gene ontology
Molecular Function:	• magnesium ion binding • single-stranded DNA binding • 3'-5'-exodeoxyribonuclease activity • exodeoxyribonuclease III activity • hydrolase activity • MutLalpha complex binding • MutSalpha complex binding • protein homodimerization activity
Cellular Component:	• nucleus • nuclear envelope
Biological Process:	• DNA replication • DNA repair • mismatch repair • DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016381 (mRNA)
NP_057465 (protein)

NM_172774 (mRNA)
NP_766362 (protein)

Location

Chr 3: 48.46 - 48.48 Mb

Chr 9: 108.92 - 108.93 Mb

Pubmed search

[1]

[2]

Three prime repair exonuclease 1, also known as TREX1, is a human gene.^[1]

This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TREX1 three prime repair exonuclease 1.

[edit] Further reading

Tolmie JL, Shillito P, Hughes-Benzie R, Stephenson JB (1996). "The Aicardi-Goutières syndrome (familial, early onset encephalopathy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis).". J. Med. Genet. 32 (11): 881–4. PMID 8592332.
Black DN, Watters GV, Andermann E, et al. (1989). "Encephalitis among Cree children in northern Quebec.". Ann. Neurol. 24 (4): 483–9. doi:10.1002/ana.410240402. PMID 3239950.
Perrino FW, Miller H, Ealey KA (1994). "Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA.". J. Biol. Chem. 269 (23): 16357–63. PMID 8206943.
Goutières F, Aicardi J, Barth PG, Lebon P (1999). "Aicardi-Goutières syndrome: an update and results of interferon-alpha studies.". Ann. Neurol. 44 (6): 900–7. doi:10.1002/ana.410440608. PMID 9851434.
Mazur DJ, Perrino FW (1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.". J. Biol. Chem. 274 (28): 19655–60. PMID 10391904.
Höss M, Robins P, Naven TJ, et al. (1999). "A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.". EMBO J. 18 (13): 3868–75. doi:10.1093/emboj/18.13.3868. PMID 10393201.
Crow YJ, Jackson AP, Roberts E, et al. (2000). "Aicardi-Goutières syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21.". Am. J. Hum. Genet. 67 (1): 213–21. PMID 10827106.
Mazur DJ, Perrino FW (2001). "Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.". J. Biol. Chem. 276 (18): 14718–27. doi:10.1074/jbc.M010051200. PMID 11278605.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Crow YJ, Black DN, Ali M, et al. (2003). "Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism.". J. Med. Genet. 40 (3): 183–7. PMID 12624136.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A (2005). "Coupling of human circadian and cell cycles by the timeless protein.". Mol. Cell. Biol. 25 (8): 3109–16. doi:10.1128/MCB.25.8.3109-3116.2005. PMID 15798197.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Yoshioka K, Yoshioka Y, Hsieh P (2006). "ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.". Mol. Cell 22 (4): 501–10. doi:10.1016/j.molcel.2006.04.023. PMID 16713580.
Chowdhury D, Beresford PJ, Zhu P, et al. (2006). "The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.". Mol. Cell 23 (1): 133–42. doi:10.1016/j.molcel.2006.06.005. PMID 16818237.
Crow YJ, Hayward BE, Parmar R, et al. (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus.". Nat. Genet. 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.