TRERF1

From Wikipedia, the free encyclopedia

Transcriptional regulating factor 1

Identifiers

TRERF1; BCAR2; HSA277276; RAPA; RP1-139D8.5; TReP-132; dJ139D8.5

External IDs

OMIM: 610322 MGI: 2442086 HomoloGene: 14129

Gene ontology
Molecular Function:	• DNA binding • transcription factor activity • transcription factor binding • zinc ion binding • DNA bending activity • RNA polymerase II transcription mediator activity • ligand-dependent nuclear receptor transcription coactivator activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • steroid biosynthetic process • cholesterol catabolic process • multicellular organismal development • homeostatic process • positive regulation of transcription, DNA-dependent • regulation of hormone biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_018415 (mRNA)
NP_060885 (protein)

NM_172622 (mRNA)
NP_766210 (protein)

Location

Chr 6: 42.3 - 42.53 Mb

Chr 17: 46.6 - 46.82 Mb

Pubmed search

[1]

[2]

Transcriptional regulating factor 1, also known as TRERF1, is a human gene.^[1]

This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRERF1 transcriptional regulating factor 1.

[edit] Further reading

Dorssers LC, Veldscholte J (1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells.". Int. J. Cancer 72 (4): 700–5. PMID 9259413.
Gizard F, Lavallée B, DeWitte F, Hum DW (2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.". J. Biol. Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
Gizard F, Lavallee B, DeWitte F, et al. (2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.". J. Biol. Chem. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
Gizard F, El-Alfy M, Duguay Y, et al. (2003). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.". Endocr. Res. 28 (4): 559–74. PMID 12530663.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gizard F, Teissier E, Dufort I, et al. (2005). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.". J. Mol. Endocrinol. 32 (2): 557–69. PMID 15072559.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gizard F, Robillard R, Barbier O, et al. (2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.". Mol. Cell. Biol. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMID 15899840.
Gizard F, Robillard R, Gross B, et al. (2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.". Mol. Cell. Biol. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMID 17015480.