TREM2

From Wikipedia, the free encyclopedia

Triggering receptor expressed on myeloid cells 2

Identifiers

TREM2; TREM-2; Trem2a; Trem2b; Trem2c

External IDs

OMIM: 605086 MGI: 1913150 HomoloGene: 10352

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• humoral immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018965 (mRNA)
NP_061838 (protein)

NM_031254 (mRNA)
NP_112544 (protein)

Location

Chr 6: 41.23 - 41.24 Mb

Chr 17: 47.81 - 47.82 Mb

Pubmed search

[1]

[2]

Triggering receptor expressed on myeloid cells 2, also known as TREM2, is a human gene.^[1]

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM2, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2.

[edit] Further reading

Bouchon A, Dietrich J, Colonna M (2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.". J. Immunol. 164 (10): 4991–5. PMID 10799849.
Paloneva J, Manninen T, Christman G, et al. (2002). "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.". Am. J. Hum. Genet. 71 (3): 656–62. PMID 12080485.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956.
Soragna D, Papi L, Ratti MT, et al. (2003). "An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene.". J. Neurol. Neurosurg. Psychiatr. 74 (6): 825–6. PMID 12754369.
Cella M, Buonsanti C, Strader C, et al. (2003). "Impaired differentiation of osteoclasts in TREM-2-deficient individuals.". J. Exp. Med. 198 (4): 645–51. doi:10.1084/jem.20022220. PMID 12913093.
Paloneva J, Mandelin J, Kiialainen A, et al. (2003). "DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.". J. Exp. Med. 198 (4): 669–75. doi:10.1084/jem.20030027. PMID 12925681.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Montalbetti L, Ratti MT, Greco B, et al. (2005). "Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes.". Funct. Neurol. 20 (2): 71–5. PMID 15966270.
Bianchin MM, Lima JE, Natel J, Sakamoto AC (2006). "The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.". Neurology 66 (4): 615–6; author reply 615–6. doi:10.1212/01.wnl.0000216105.11788.0f. PMID 16505336.