Transportin 1

From Wikipedia, the free encyclopedia

Transportin 1

PDB rendering based on 1qbk.

Available structures: 1qbk, 2h4m, 2ot8

Identifiers

Symbol(s)

TNPO1; IPO2; KPNB2; MIP; MIP1; TRN

External IDs

OMIM: 602901 MGI: 2681523 HomoloGene: 5358

Gene ontology
Molecular Function:	• protein binding • nuclear localization sequence binding • protein transporter activity
Cellular Component:	• nucleus • nuclear pore • cytoplasm
Biological Process:	• protein import into nucleus, docking • protein import into nucleus, translocation • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002270 (mRNA)
NP_002261 (protein)

NM_001048267 (mRNA)
NP_001041732 (protein)

Location

Chr 5: 72.15 - 72.25 Mb

Chr 13: 99.94 - 100.03 Mb

Pubmed search

[1]

[2]

Transportin 1, also known as TNPO1, is a human gene.^[1]

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: TNPO1 transportin 1.

[edit] Further reading

Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader.". Front. Biosci. 2: d578–87. PMID 9366553.
Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.". Mol. Med. 4 (3): 138–43. PMID 9562972.
Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. PMID 1631159.
Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. PMID 7604027.
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.". Nature 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
Michael WM, Choi M, Dreyfuss G (1996). "A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway.". Cell 83 (3): 415–22. PMID 8521471.
Pollard VW, Michael WM, Nakielny S, et al. (1996). "A novel receptor-mediated nuclear protein import pathway.". Cell 86 (6): 985–94. PMID 8808633.
Nakielny S, Siomi MC, Siomi H, et al. (1997). "Transportin: nuclear transport receptor of a novel nuclear protein import pathway.". Exp. Cell Res. 229 (2): 261–6. doi:10.1006/excr.1996.0369. PMID 8986607.
Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. PMID 9144189.
Fridell RA, Truant R, Thorne L, et al. (1997). "Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.". J. Cell. Sci. 110 ( Pt 11): 1325–31. PMID 9202393.
Gallay P, Hope T, Chin D, Trono D (1997). "HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. PMID 9275210.
Siomi MC, Eder PS, Kataoka N, et al. (1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.". J. Cell Biol. 138 (6): 1181–92. PMID 9298975.
Henderson BR, Percipalle P (1998). "Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.". J. Mol. Biol. 274 (5): 693–707. doi:10.1006/jmbi.1997.1420. PMID 9405152.
Efthymiadis A, Briggs LJ, Jans DA (1998). "The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties.". J. Biol. Chem. 273 (3): 1623–8. PMID 9430704.
Vodicka MA, Koepp DM, Silver PA, Emerman M (1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection.". Genes Dev. 12 (2): 175–85. PMID 9436978.
Popov S, Rexach M, Zybarth G, et al. (1998). "Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.". EMBO J. 17 (4): 909–17. doi:10.1093/emboj/17.4.909. PMID 9463369.
Popov S, Rexach M, Ratner L, et al. (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex.". J. Biol. Chem. 273 (21): 13347–52. PMID 9582382.
Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.". J. Virol. 72 (7): 6004–13. PMID 9621063.