Transmembrane domain of ABC transporters

ABC transporter transmembrane region
Identifiers
Symbol	ABC_membrane
Pfam	PF00664
InterPro	IPR001140
PROSITE	PDOC00364
SCOP	1pf4
TCDB	3.A.1
OPM family	18
OPM protein	1pf4
Available PDB structures: 2hyd 3b60

ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam PF00005) have two such regions.^[1].^[2]^[3]^[4]^[5]^[6]

[edit] Human proteins containing this domain

^ Kerr ID (2002). "Structure and association of ATP-binding cassette transporter nucleotide-binding domains". Biochim. Biophys. Acta 1561 (1): -. PMID 11988180.
^ Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). "Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter". Structure 9 (7): -. PMID 11470432.
^ Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). "The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter". J. Biol. Chem. 276 (34): -. PMID 11402022.
^ Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). "Crystal structure of the ATP-binding subunit of an ABC transporter". Nature 396 (6712): 703–707. doi:10.1038/25393. PMID 9872322.
^ Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). "Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis". EMBO J. 19 (22): -. doi:10.1093/emboj/19.22.5951. PMID 11080142.
^ Wiley DC, Gaudet R (2001). "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): -. doi:10.1093/emboj/20.17.4964. PMID 11532960.