Transcortin

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Structure of corticosteroid-binding globulin in complex with cortisol.
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
Identifiers
Symbol	SERPINA6
Alt. Symbols	CBG
Entrez	866
HUGO	1540
OMIM	122500
RefSeq	NM_001750
UniProt	P08185
Other data
Locus	Chr. 14 q32.1

Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.

It is an alpha-globulin.

1 Binding
2 Production
3 See also
4 External links

[edit] Binding

Transcortin binds several steroid hormones:

Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.

Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.

Progesterone

[edit] Production

Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.

[edit] See also

[edit] External links

MeSH Transcortin

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v • d • e Proteins: carrier proteins

Hormone	Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin

Metal/element	calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor)

Vitamin	Retinol binding protein (4) - Transcobalamin

Other	Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein

v • d • e Globulins: alpha globulins

Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - Alpha 2-antiplasmin - Antithrombin - Ceruloplasmin - Haptoglobin - Heparin cofactor II - Orosomucoid - Retinol binding protein - Transcortin

v • d • e Serpins

inhibitory	Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor · SERPINA4 · SERPINA6 · SERPINB1 · SERPINB3 · SERPINB4 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13 · SERPINE2 · SERPINF2

Cross class inhibitory	MENT · SCCA-1 · crmA

noninhibitory	Heat shock protein 47 · Maspin · Ovalbumin · SERPINF1 · Thyroxine-binding globulin · Transcortin · SERPINF1