Trans-pentaprenyltranstransferase

From Wikipedia, the free encyclopedia

In enzymology, a trans-pentaprenyltranstransferase (EC 2.5.1.33) is an enzyme that catalyzes the chemical reaction

all-trans-pentaprenyl diphosphate + isopentenyl diphosphate diphosphate + all-trans-hexaprenyl diphosphate

Thus, the two substrates of this enzyme are all-trans-pentaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-hexaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase. Other names in common use include all-trans-hexaprenyl-diphosphate synthase, hexaprenyl diphosphate synthase, and hexaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.

[edit] References

• IUBMB entry for 2.5.1.33
• BRENDA references for 2.5.1.33 (Recommended.)
• PubMed references for 2.5.1.33
• PubMed Central references for 2.5.1.33
• Google Scholar references for 2.5.1.33
• Fujii H, Koyama T, Ogura K (1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26 Separation of two essential components". J. Biol. Chem. 257: 14610–2. PMID 7174655. 

[edit] External links

The CAS registry number for this enzyme class is 83745-07-7.

• IUBMB entry for 2.5.1.33

• KEGG entry for 2.5.1.33

• BRENDA entry for 2.5.1.33

• NiceZyme view of 2.5.1.33

• EC2PDB: PDB structures for 2.5.1.33

• PRIAM entry for 2.5.1.33

• PUMA2 entry for 2.5.1.33

• IntEnz: Integrated Enzyme entry for 2.5.1.33

• MetaCyc entry for 2.5.1.33

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0048045: trans-pentaprenyltranstransferase

• AMIGO entry for GO code 0048045: trans-pentaprenyltranstransferase