Trans-hexaprenyltranstransferase

From Wikipedia, the free encyclopedia

In enzymology, a trans-hexaprenyltranstransferase (EC 2.5.1.30) is an enzyme that catalyzes the chemical reaction

all-trans-hexaprenyl diphosphate + isopentenyl diphosphate diphosphate + all-trans-heptaprenyl diphosphate

Thus, the two substrates of this enzyme are all-trans-hexaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase. Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, heptaprenyl diphosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 2E8T, 2E8U, 2E8V, 2E8W, 2E8X, 2E90, 2E91, 2E92, 2E93, 2E94, and 2E95.

[edit] References

• IUBMB entry for 2.5.1.30
• BRENDA references for 2.5.1.30 (Recommended.)
• PubMed references for 2.5.1.30
• PubMed Central references for 2.5.1.30
• Google Scholar references for 2.5.1.30
• Takahashi I, Ogura K, Seto S (1980). "Heptaprenyl pyrophosphate synthetase from Bacillus subtilis". J. Biol. Chem. 255: 4539–43. PMID 6768722. 

[edit] External links

The CAS registry number for this enzyme class is 74506-59-5.

• IUBMB entry for 2.5.1.30

• KEGG entry for 2.5.1.30

• BRENDA entry for 2.5.1.30

• NiceZyme view of 2.5.1.30

• EC2PDB: PDB structures for 2.5.1.30

• PRIAM entry for 2.5.1.30

• PUMA2 entry for 2.5.1.30

• IntEnz: Integrated Enzyme entry for 2.5.1.30

• MetaCyc entry for 2.5.1.30

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000010: trans-hexaprenyltranstransferase

• AMIGO entry for GO code 0000010: trans-hexaprenyltranstransferase