Trans-cinnamate 4-monooxygenase

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In enzymology, a trans-cinnamate 4-monooxygenase (EC 1.14.13.11) is an enzyme that catalyzes the chemical reaction

trans-cinnamate + NADPH + H⁺ + O₂ $\rightleftharpoons$ 4-hydroxycinnamate + NADP⁺ + H₂O

The 4 substrates of this enzyme are trans-cinnamate, NADPH, H⁺, and O₂, whereas its 3 products are 4-hydroxycinnamate, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include cinnamic acid 4-hydroxylase, oxygenase, cinnamate 4-mono-, CA4H, cytochrome P450 cinnamate 4-hydroxylase, cinnamate 4-hydroxylase, cinnamate 4-monooxygenase, cinnamate hydroxylase, cinnamic 4-hydroxylase, cinnamic acid 4-monooxygenase, cinnamic acid p-hydroxylase, hydroxylase, cinnamate 4-, t-cinnamic acid hydroxylase, trans-cinnamate 4-hydroxylase, and trans-cinnamic acid 4-hydroxylase. This enzyme participates in phenylalanine metabolism and phenylpropanoid biosynthesis. It employs one cofactor, heme.

[edit] References

IUBMB entry for 1.14.13.11
BRENDA references for 1.14.13.11 (Recommended.)
PubMed references for 1.14.13.11
PubMed Central references for 1.14.13.11
Google Scholar references for 1.14.13.11
Potts JR, Weklych R, Conn EE, Rowell J (1974). "The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450". J. Biol. Chem. 249: 5019–26. PMID 4153152.
Russell DW, Conn EE (1967). "The cinnamic acid 4-hydroxylase of pea seedlings". Arch. Biochem. Biophys. 122: 256–8. doi:10.1016/0003-9861(67)90150-6. PMID 4383827.