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| Trans-activation response element (TAR) |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
56.7 nucleotides |
| Avg identity: |
91% |
|
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin acts as a binding site for the Tat protein and this interaction stimulates the activity of the long terminal repeat promoter.[1]
[edit] References
- ^ Kulinski, T; Olejniczak M, Huthoff H, Bielecki L, Pachulska-Wieczorek K, Das AT, Berkhout B, Adamiak RW (2003). "The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair". J Biol Chem 278: 38892–38901. doi:10.1074/jbc.M301939200. PMID 12882959.
[edit] External links
