Trans-L-3-hydroxyproline dehydratase

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In enzymology, a trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) is an enzyme that catalyzes the chemical reaction

trans-L-3-hydroxyproline Delta₁-pyrroline 2-carboxylate + H₂O

Hence, this enzyme has one substrate, trans-L-3-hydroxyproline, and two products, Delta1-pyrroline 2-carboxylate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline-2-carboxylate-forming). This enzyme is also called trans-L-3-hydroxyproline hydro-lyase.

[edit] References

• IUBMB entry for 4.2.1.77
• BRENDA references for 4.2.1.77 (Recommended.)
• PubMed references for 4.2.1.77
• PubMed Central references for 4.2.1.77
• Google Scholar references for 4.2.1.77
• Ramaswamy SG (1983). "Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides". Fed. Proc. 42: 2232. 

[edit] External links

• IUBMB entry for 4.2.1.77

• KEGG entry for 4.2.1.77

• BRENDA entry for 4.2.1.77

• NiceZyme view of 4.2.1.77

• EC2PDB: PDB structures for 4.2.1.77

• PRIAM entry for 4.2.1.77

• PUMA2 entry for 4.2.1.77

• IntEnz: Integrated Enzyme entry for 4.2.1.77

• MetaCyc entry for 4.2.1.77

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050346: trans-L-3-hydroxyproline dehydratase

• AMIGO entry for GO code 0050346: trans-L-3-hydroxyproline dehydratase