Trans-2-enoyl-CoA reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, a trans-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.38) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP⁺ trans-2,3-dehydroacyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-CoA and NADP⁺, whereas its 3 products are trans-2,3-dehydroacyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZSY.

[edit] References

• IUBMB entry for 1.3.1.38
• BRENDA references for 1.3.1.38 (Recommended.)
• PubMed references for 1.3.1.38
• PubMed Central references for 1.3.1.38
• Google Scholar references for 1.3.1.38
• H (Tokyo). "Studies on the metabolism of unsaturated fatty acids. IX Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli". J. Biochem.: 1649–54. PMID 6759504. 

[edit] External links

The CAS registry number for this enzyme class is 77649-64-0.

• IUBMB entry for 1.3.1.38

• KEGG entry for 1.3.1.38

• BRENDA entry for 1.3.1.38

• NiceZyme view of 1.3.1.38

• EC2PDB: PDB structures for 1.3.1.38

• PRIAM entry for 1.3.1.38

• PUMA2 entry for 1.3.1.38

• IntEnz: Integrated Enzyme entry for 1.3.1.38

• MetaCyc entry for 1.3.1.38

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019166: trans-2-enoyl-CoA reductase (NADPH)

• AMIGO entry for GO code 0019166: trans-2-enoyl-CoA reductase (NADPH)