Trans-2-enoyl-CoA reductase (NAD+)

From Wikipedia, the free encyclopedia

In enzymology, a trans-2-enoyl-CoA reductase (NAD+) (EC 1.3.1.44) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NAD⁺ trans-didehydroacyl-CoA + NADH + H⁺

Thus, the two substrates of this enzyme are acyl-CoA and NAD⁺, whereas its 3 products are trans-didehydroacyl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NAD+ trans-2-oxidoreductase. This enzyme is also called trans-2-enoyl-CoA reductase (NAD+). This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 1.3.1.44
• BRENDA references for 1.3.1.44 (Recommended.)
• PubMed references for 1.3.1.44
• PubMed Central references for 1.3.1.44
• Google Scholar references for 1.3.1.44
• Inui H, Miyatake K, Nakano Y, Kitaoka S (Tokyo). "Purification and some properties of short chain-length specific trans-2-enoyl-CoA reductase in mitochondria of Euglena gracilis". J. Biochem.: 995–1000. PMID 3102464. 

[edit] External links

The CAS registry number for this enzyme class is 77649-64-0.

• IUBMB entry for 1.3.1.44

• KEGG entry for 1.3.1.44

• BRENDA entry for 1.3.1.44

• NiceZyme view of 1.3.1.44

• EC2PDB: PDB structures for 1.3.1.44

• PRIAM entry for 1.3.1.44

• PUMA2 entry for 1.3.1.44

• IntEnz: Integrated Enzyme entry for 1.3.1.44

• MetaCyc entry for 1.3.1.44

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050343: trans-2-enoyl-CoA reductase (NAD+)

• AMIGO entry for GO code 0050343: trans-2-enoyl-CoA reductase (NAD+)