Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) is an enzyme that catalyzes the chemical reaction
- trans-1,2-dihydrobenzene-1,2-diol + NADP+
catechol + NADPH + H+
Thus, the two substrates of this enzyme are trans-1,2-dihydrobenzene-1,2-diol and NADP+, whereas its 3 products are catechol, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450.
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[edit] Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2HDJ, 2IPJ, 2O48, 2O4U, and 2POQ.
[edit] References
- IUBMB entry for 1.3.1.20
- BRENDA references for 1.3.1.20 (Recommended.)
- PubMed references for 1.3.1.20
- PubMed Central references for 1.3.1.20
- Google Scholar references for 1.3.1.20
- AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I (1959). "Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol". Biochim. Biophys. Acta. 33: 111–9. doi:. PMID 13651190.
[edit] External links
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- The CAS registry number for this enzyme class is 37255-32-6.
[edit] Gene Ontology (GO) codes
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