TRAT1

From Wikipedia, the free encyclopedia

T cell receptor associated transmembrane adaptor 1

Identifiers

TRAT1; HSPC062; TCRIM; TRIM

External IDs

OMIM: 604962 MGI: 1924897 HomoloGene: 41130

Gene ontology
Molecular Function:	• transmembrane receptor protein tyrosine kinase adaptor protein activity
Cellular Component:	• plasma membrane • integral to plasma membrane • T cell receptor complex
Biological Process:	• negative regulation of receptor recycling • immune response • cellular defense response • signal transduction • positive regulation of calcium-mediated signaling • positive regulation of T cell receptor signaling pathway • negative regulation of transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016388 (mRNA)
NP_057472 (protein)

NM_198297 (mRNA)
NP_938039 (protein)

Location

Chr 3: 110.02 - 110.06 Mb

Chr 16: 48.65 - 48.69 Mb

Pubmed search

[1]

[2]

T cell receptor associated transmembrane adaptor 1, also known as TRAT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1.

[edit] Further reading

Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling.". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796.
Bruyns E, Marie-Cardine A, Kirchgessner H, et al. (1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.". J. Exp. Med. 188 (3): 561–75. PMID 9687533.
Hübener C, Mincheva A, Lichter P, et al. (2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM).". Immunogenetics 51 (2): 154–8. PMID 10663578.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.". J. Exp. Med. 193 (11): 1269–84. PMID 11390434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.