TRAPPC3

From Wikipedia, the free encyclopedia

Trafficking protein particle complex 3

PDB rendering based on 1sz7.

Available structures: 1sz7, 1wc8, 1wc9, 2c0j, 2cfh, 2j3r, 2j3t, 2j3w, 2pwn

Identifiers

Symbol(s)

TRAPPC3; BET3

External IDs

MGI: 1351486 HomoloGene: 6399

Gene ontology
Cellular Component:	• Golgi membrane • endoplasmic reticulum • cytosol
Biological Process:	• transport • ER to Golgi vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014408 (mRNA)
NP_055223 (protein)

XM_990561 (mRNA)
XP_995655 (protein)

Location

Chr 1: 36.37 - 36.39 Mb

Chr 4: 125.76 - 125.78 Mb

Pubmed search

[1]

[2]

Trafficking protein particle complex 3, also known as TRAPPC3, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRAPPC3 trafficking protein particle complex 3.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Sacher M, Jiang Y, Barrowman J, et al. (1998). "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.". EMBO J. 17 (9): 2494–503. doi:10.1093/emboj/17.9.2494. PMID 9564032.
Barrowman J, Sacher M, Ferro-Novick S (2000). "TRAPP stably associates with the Golgi and is required for vesicle docking.". EMBO J. 19 (5): 862–9. doi:10.1093/emboj/19.5.862. PMID 10698928.
Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes.". Nature 415 (6868): 141–7. doi:10.1038/415141a. PMID 11805826.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kim YG, Sohn EJ, Seo J, et al. (2005). "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP.". Nat. Struct. Mol. Biol. 12 (1): 38–45. doi:10.1038/nsmb871. PMID 15608655.
Turnbull AP, Kümmel D, Prinz B, et al. (2005). "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.". EMBO J. 24 (5): 875–84. doi:10.1038/sj.emboj.7600565. PMID 15692564.
Loh E, Peter F, Subramaniam VN, Hong W (2005). "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.". J. Cell. Sci. 118 (Pt 6): 1209–22. doi:10.1242/jcs.01723. PMID 15728249.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kim MS, Yi MJ, Lee KH, et al. (2006). "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.". Traffic 6 (12): 1183–95. doi:10.1111/j.1600-0854.2005.00352.x. PMID 16262728.
Kümmel D, Müller JJ, Roske Y, et al. (2006). "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.". J. Mol. Biol. 361 (1): 22–32. doi:10.1016/j.jmb.2006.06.012. PMID 16828797.
Yu S, Satoh A, Pypaert M, et al. (2006). "mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.". J. Cell Biol. 174 (3): 359–68. doi:10.1083/jcb.200603044. PMID 16880271.
Kümmel D, Heinemann U, Veit M (2006). "Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.". Proc. Natl. Acad. Sci. U.S.A. 103 (34): 12701–6. doi:10.1073/pnas.0603513103. PMID 16908848.