TRAP1

From Wikipedia, the free encyclopedia

TNF receptor-associated protein 1

Identifiers

TRAP1; HSP75; HSP90L

External IDs

OMIM: 606219 MGI: 1915265 HomoloGene: 9457

Gene ontology
Molecular Function:	• nucleotide binding • tumor necrosis factor receptor binding • ATP binding • unfolded protein binding
Cellular Component:	• cellular_component • mitochondrion
Biological Process:	• protein folding • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016292 (mRNA)
NP_057376 (protein)

NM_026508 (mRNA)
NP_080784 (protein)

Location

Chr 16: 3.65 - 3.71 Mb

Chr 16: 3.96 - 3.99 Mb

Pubmed search

[1]

[2]

TNF receptor-associated protein 1, also known as TRAP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRAP1 TNF receptor-associated protein 1.

[edit] Further reading

Song HY, Dunbar JD, Zhang YX, et al. (1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.". J. Biol. Chem. 270 (8): 3574–81. PMID 7876093.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Chen CF, Chen Y, Dai K, et al. (1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.". Mol. Cell. Biol. 16 (9): 4691–9. PMID 8756626.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Charng MJ, Zhang D, Kinnunen P, Schneider MD (1998). "A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor.". J. Biol. Chem. 273 (16): 9365–8. PMID 9545258.
Simmons AD, Musy MM, Lopes CS, et al. (1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.". Hum. Mol. Genet. 8 (12): 2155–64. PMID 10545594.
Felts SJ, Owen BA, Nguyen P, et al. (2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.". J. Biol. Chem. 275 (5): 3305–12. PMID 10652318.
Wurthner JU, Frank DB, Felici A, et al. (2001). "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.". J. Biol. Chem. 276 (22): 19495–502. doi:10.1074/jbc.M006473200. PMID 11278302.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Masuda Y, Shima G, Aiuchi T, et al. (2004). "Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.". J. Biol. Chem. 279 (41): 42503–15. doi:10.1074/jbc.M404256200. PMID 15292218.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains.". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMID 16482509.
Im CN, Lee JS, Zheng Y, Seo JS (2007). "Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species.". J. Cell. Biochem. 100 (2): 474–86. doi:10.1002/jcb.21064. PMID 16927372.