TRAM2

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Translocation associated membrane protein 2
Identifiers
Symbol(s) TRAM2; KIAA0057
External IDs OMIM: 608485 MGI: 1924817 HomoloGene: 8183
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9697 170829
Ensembl ENSG00000065308 ENSMUSG00000041779
Uniprot Q15035 Q924Z5
Refseq NM_012288 (mRNA)
NP_036420 (protein)		 NM_133252 (mRNA)
NP_573515 (protein)
Location Chr 6: 52.47 - 52.55 Mb Chr 1: 20.99 - 21.06 Mb
Pubmed search [1] [2]

Translocation associated membrane protein 2, also known as TRAM2, is a human gene.[1]

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: TRAM2 translocation associated membrane protein 2.

[edit] Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044. 
  • Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library.". Genomics 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • Onuchic LF, Mrug M, Lakings AL, et al. (2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene.". Mamm. Genome 10 (12): 1175–8. PMID 10594243. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.". Mol. Cell. Biol. 23 (23): 8773–85. PMID 14612417. 
  • Stefanovic B, Stefanovic L, Schnabl B, et al. (2004). "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.". Mol. Cell. Biol. 24 (4): 1758–68. PMID 14749390. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
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