TRAK2

From Wikipedia, the free encyclopedia

Trafficking protein, kinesin binding 2

Identifiers

TRAK2; ALS2CR3; CALS-C; GRIF-1; GRIF1; KIAA0549; OIP98

External IDs

OMIM: 607334 MGI: 1918077 HomoloGene: 22861

Gene ontology
Molecular Function:	• transporter activity • GABA receptor binding
Cellular Component:	• cytoplasm • plasma membrane
Biological Process:	• neurotransmitter transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_015049 (mRNA)
NP_055864 (protein)

XM_987233 (mRNA)
XP_992327 (protein)

Location

Chr 2: 201.95 - 202.02 Mb

Chr 1: 58.84 - 58.92 Mb

Pubmed search

[1]

[2]

Trafficking protein, kinesin binding 2, also known as TRAK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRAK2 trafficking protein, kinesin binding 2.

[edit] Further reading

Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
Hadano S, Yanagisawa Y, Skaug J, et al. (2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.". Genomics 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
Beck M, Brickley K, Wilkinson HL, et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1.". J. Biol. Chem. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.". J. Biol. Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Gilbert SL, Zhang L, Forster ML, et al. (2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.". Nat. Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.
Smith MJ, Pozo K, Brickley K, Stephenson FA (2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes.". J. Biol. Chem. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
Grishin A, Li H, Levitan ES, Zaks-Makhina E (2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1.". J. Biol. Chem. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.