TRAK1

From Wikipedia, the free encyclopedia

Trafficking protein, kinesin binding 1

Identifiers

TRAK1; OIP106

External IDs

OMIM: 608112 MGI: 1914345 HomoloGene: 86983

Gene ontology
Molecular Function:	• protein binding • kinesin-associated mitochondrial adaptor activity • GABA receptor binding
Cellular Component:	• nucleus • mitochondrion
Biological Process:	• regulation of transcription from RNA polymerase II promoter • protein amino acid O-linked glycosylation • protein targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001042646 (mRNA)
NP_001036111 (protein)

XM_001001035 (mRNA)
XP_001001035 (protein)

Location

Chr 3: 42.11 - 42.24 Mb

Chr 9: 121.15 - 121.32 Mb

Pubmed search

[1]

[2]

Trafficking protein, kinesin binding 1, also known as TRAK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRAK1 trafficking protein, kinesin binding 1.

[edit] Further reading

Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.". J. Biol. Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Iyer SP, Hart GW (2003). "Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity.". J. Biol. Chem. 278 (27): 24608–16. doi:10.1074/jbc.M300036200. PMID 12724313.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553.
Gilbert SL, Zhang L, Forster ML, et al. (2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.". Nat. Genet. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.