TRAIL

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Tumor necrosis factor (ligand) superfamily, member 10
PDB rendering based on 1d0g.
Available structures: 1d0g, 1d2q, 1d4v, 1dg6, 1du3
Identifiers
Symbol(s)	TNFSF10; APO2L; Apo-2L; CD253; TL2; TRAIL
External IDs	OMIM: 603598 MGI: 107414 HomoloGene: 2824
Gene ontology Molecular Function: • signal transducer activity • cytokine activity • tumor necrosis factor receptor binding • zinc ion binding • metal ion binding Cellular Component: • extracellular space • soluble fraction • integral to plasma membrane • membrane Biological Process: • apoptosis • induction of apoptosis • immune response • signal transduction • cell-cell signaling • positive regulation of I-kappaB kinase/NF-kappaB cascade
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8743	22035
Ensembl	ENSG00000121858	ENSMUSG00000039304
Uniprot	P50591	Q3TZR6
Refseq	NM_003810 (mRNA) NP_003801 (protein)	NM_009425 (mRNA) NP_033451 (protein)
Location	Chr 3: 173.71 - 173.72 Mb	Chr 3: 27.51 - 27.53 Mb
Pubmed search	[1]	[2]

TNF-related apoptosis-inducing ligand (TRAIL), in the field of cell biology, is a ligand molecule which induces the process of cell death called apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.

In humans, the gene that encodes for TRAIL is located at chromosome 3q26.

TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent.

TRAIL has also been designated CD253 (cluster of differentiation 253).

[edit] Further reading

[edit] External links

• PDB 1D2Q
• MeSH TRAIL+Protein

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