TRAF interacting protein

From Wikipedia, the free encyclopedia

Identifiers

TRAIP; TRIP; RNF206

External IDs

OMIM: 605958 MGI: 1096377 HomoloGene: 31343

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Biological Process:	• induction of apoptosis • signal transduction • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005879 (mRNA)
NP_005870 (protein)

XM_976945 (mRNA)
XP_982039 (protein)

Location

Chr 3: 49.84 - 49.87 Mb

Chr 9: 107.81 - 107.83 Mb

Pubmed search

[1]

[2]

TRAF interacting protein, also known as TRAIP, is a human gene.^[1]

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRAIP TRAF interacting protein.

[edit] Further reading

Beckly JB, Hancock L, Geremia A, et al.. "Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease.". Inflamm. Bowel Dis. 14 (4): 500-7. doi:10.1002/ibd.20365. PMID 18200509.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Regamey A, Hohl D, Liu JW, et al. (2004). "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.". J. Exp. Med. 198 (12): 1959-64. doi:10.1084/jem.20031187. PMID 14676304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.". Nucleic Acids Res. 26 (15): 3460-7. PMID 9671805.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Lee SY, Lee SY, Choi Y (1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.". J. Exp. Med. 185 (7): 1275-85. PMID 9104814.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.