TRAF6

From Wikipedia, the free encyclopedia

TNF receptor-associated factor 6

PDB rendering based on 1lb4.

Available structures: 1lb4, 1lb5, 1lb6, 2jmd

Identifiers

Symbol(s)

TRAF6; MGC:3310; RNF85

External IDs

OMIM: 602355 MGI: 108072 HomoloGene: 3395

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • signal transducer activity • protein binding • zinc ion binding • metal ion binding
Biological Process:	• protein polyubiquitination • positive regulation of T cell cytokine production • ubiquitin cycle • signal transduction • activation of NF-kappaB-inducing kinase • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • T cell receptor signaling pathway • positive regulation of T cell activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004620 (mRNA)
NP_004611 (protein)

NM_009424 (mRNA)
NP_033450 (protein)

Location

Chr 11: 36.47 - 36.49 Mb

Chr 2: 101.48 - 101.5 Mb

Pubmed search

[1]

[2]

TRAF6 is a TRAF human protein.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.^[1]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

[edit] References

^ Entrez Gene: TRAF6 TNF receptor-associated factor 6.

[edit] Further reading

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389–400. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system.". Immunol. Rev. 208: 30–49. doi:10.1111/j.0105-2896.2005.00327.x. PMID 16313339.