TRAF5

From Wikipedia, the free encyclopedia

TNF receptor-associated factor 5

Identifiers

TRAF5; MGC:39780; RNF84

External IDs

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • zinc ion binding • metal ion binding
Biological Process:	• signal transduction • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001033910 (mRNA)
NP_001029082 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 209.57 - 209.61 Mb

Chr 1: 193.7 - 193.77 Mb

Pubmed search

[1]

[2]

TNF receptor-associated factor 5, also known as TRAF5, is a human gene.

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.^[1]

[edit] References

^ Entrez Gene: TRAF5 TNF receptor-associated factor 5.

[edit] Further reading

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389–400. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Nakano H, Oshima H, Chung W, et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.". J. Biol. Chem. 271 (25): 14661–4. PMID 8663299.
Ishida TK, Tojo T, Aoki T, et al. (1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9437–42. PMID 8790348.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Ansieau S, Scheffrahn I, Mosialos G, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. PMID 8943059.
Aizawa S, Nakano H, Ishida T, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.". J. Biol. Chem. 272 (4): 2042–5. PMID 8999898.
Tang XX, Pleasure DE, Ikegaki N (1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors.". Genomics 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477.
Hsu H, Solovyev I, Colombero A, et al. (1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.". J. Biol. Chem. 272 (21): 13471–4. PMID 9153189.
Marsters SA, Ayres TM, Skubatch M, et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.". J. Biol. Chem. 272 (22): 14029–32. PMID 9162022.
Nakano H, Shindo M, Yamada K, et al. (1997). "Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.". Genomics 42 (1): 26–32. PMID 9177772.
Song HY, Régnier CH, Kirschning CJ, et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. PMID 9275204.
Kawamata S, Hori T, Imura A, et al. (1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.". J. Biol. Chem. 273 (10): 5808–14. PMID 9488716.
Mizushima S, Fujita M, Ishida T, et al. (1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).". Gene 207 (2): 135–40. PMID 9511754.
Akiba H, Nakano H, Nishinaka S, et al. (1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.". J. Biol. Chem. 273 (21): 13353–8. PMID 9582383.
McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.". J. Biol. Chem. 273 (27): 16968–75. PMID 9642260.
Pullen SS, Miller HG, Everdeen DS, et al. (1998). "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.". Biochemistry 37 (34): 11836–45. doi:10.1021/bi981067q. PMID 9718306.
Wong BR, Josien R, Lee SY, et al. (1998). "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.". J. Biol. Chem. 273 (43): 28355–9. PMID 9774460.
Nishitoh H, Saitoh M, Mochida Y, et al. (1998). "ASK1 is essential for JNK/SAPK activation by TRAF2.". Mol. Cell 2 (3): 389–95. PMID 9774977.
Tsukamoto N, Kobayashi N, Azuma S, et al. (1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1234–9. PMID 9990007.