TRAF4

From Wikipedia, the free encyclopedia

TNF receptor-associated factor 4

Identifiers

TRAF4; CART1; MLN62; RNF83

External IDs

OMIM: 602464 MGI: 1202880 HomoloGene: 3173

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• signal transduction • multicellular organismal development • respiratory gaseous exchange • respiratory tube development • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_145751 (mRNA)
NP_665694 (protein)

NM_009423 (mRNA)
NP_033449 (protein)

Location

Chr 17: 24.1 - 24.1 Mb

Chr 11: 77.97 - 77.98 Mb

Pubmed search

[1]

[2]

TNF receptor-associated factor 4, also known as TRAF4, is a human gene.^[1]

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRAF4 TNF receptor-associated factor 4.

[edit] Further reading

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389–400. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Tomasetto C, Régnier C, Moog-Lutz C, et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
Régnier CH, Tomasetto C, Moog-Lutz C, et al. (1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.". J. Biol. Chem. 270 (43): 25715–21. PMID 7592751.
Masson R, Régnier CH, Chenard MP, et al. (1998). "Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.". Mech. Dev. 71 (1-2): 187–91. PMID 9507120.
Krajewska M, Krajewski S, Zapata JM, et al. (1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.". Am. J. Pathol. 152 (6): 1549–61. PMID 9626059.
Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. PMID 10514511.
Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
Régnier CH, Masson R, Kedinger V, et al. (2002). "Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5585–90. doi:10.1073/pnas.052124799. PMID 11943846.
Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
Glauner H, Siegmund D, Motejadded H, et al. (2002). "Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4).". Eur. J. Biochem. 269 (19): 4819–29. PMID 12354113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sax JK, El-Deiry WS (2003). "Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene.". J. Biol. Chem. 278 (38): 36435–44. doi:10.1074/jbc.M303191200. PMID 12788948.
Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H (2003). "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase.". Leuk. Res. 27 (8): 687–94. PMID 12801526.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ma BY, Mikolajczak SA, Danesh A, et al. (2005). "The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells.". Blood 106 (6): 2002–10. doi:10.1182/blood-2004-04-1622. PMID 15941918.
Takeshita F, Ishii KJ, Kobiyama K, et al. (2005). "TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.". Eur. J. Immunol. 35 (8): 2477–85. doi:10.1002/eji.200526151. PMID 16052631.
Abell AN, Johnson GL (2006). "MEKK4 is an effector of the embryonic TRAF4 for JNK activation.". J. Biol. Chem. 280 (43): 35793–6. doi:10.1074/jbc.C500260200. PMID 16157600.