TRAF3

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TNF receptor-associated factor 3
PDB rendering based on 1flk.
Available structures: 1flk, 1fll, 1kzz, 1l0a, 1rf3, 1zms, 2gkw
Identifiers
Symbol(s) TRAF3; LAP1; CAP-1; CD40bp; CRAF1
External IDs OMIM: 601896 MGI: 108041 HomoloGene: 7981
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7187 22031
Ensembl ENSG00000131323 ENSMUSG00000021277
Uniprot Q13114 Q60803
Refseq NM_003300 (mRNA)
NP_003291 (protein)		 NM_001048206 (mRNA)
NP_001041671 (protein)
Location Chr 14: 102.41 - 102.44 Mb Chr 12: 111.61 - 111.71 Mb
Pubmed search [1] [2]

TNF receptor-associated factor 3, also known as TRAF3, is a human gene.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[1]

[edit] References

  1. ^ Entrez Gene: TRAF3 TNF receptor-associated factor 3.

[edit] Further reading

  • Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389-400. PMID 11384837. 
  • Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482-91. doi:10.1038/sj.onc.1204788. PMID 11607847. 
  • Saha SK, Cheng G (2006). "TRAF3: a new regulator of type I interferons.". Cell Cycle 5 (8): 804-7. PMID 16582590. 
  • Hu HM, O'Rourke K, Boguski MS, Dixit VM (1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40.". J. Biol. Chem. 269 (48): 30069-72. PMID 7527023. 
  • Sato T, Irie S, Reed JC (1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.". FEBS Lett. 358 (2): 113-8. PMID 7530216. 
  • Cheng G, Cleary AM, Ye ZS, et al. (1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling.". Science 267 (5203): 1494-8. PMID 7533327. 
  • Mosialos G, Birkenbach M, Yalamanchili R, et al. (1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.". Cell 80 (3): 389-99. PMID 7859281. 
  • Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.". Cell 84 (2): 299-308. PMID 8565075. 
  • Hsu H, Huang J, Shu HB, et al. (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.". Immunity 4 (4): 387-96. PMID 8612133. 
  • Butch ER, Guan KL (1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.". J. Biol. Chem. 271 (8): 4230-5. PMID 8626767. 
  • Gedrich RW, Gilfillan MC, Duckett CS, et al. (1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins.". J. Biol. Chem. 271 (22): 12852-8. PMID 8662842. 
  • Nakano H, Oshima H, Chung W, et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.". J. Biol. Chem. 271 (25): 14661-4. PMID 8663299. 
  • Rothe M, Xiong J, Shu HB, et al. (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241-6. PMID 8710854. 
  • Hubberstey A, Yu G, Loewith R, et al. (1997). "Mammalian CAP interacts with CAP, CAP2, and actin.". J. Cell. Biochem. 61 (3): 459-66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950. 
  • Ansieau S, Scheffrahn I, Mosialos G, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053-8. PMID 8943059. 
  • VanArsdale TL, VanArsdale SL, Force WR, et al. (1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460-5. PMID 9122217. 
  • Marsters SA, Ayres TM, Skubatch M, et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.". J. Biol. Chem. 272 (22): 14029-32. PMID 9162022. 
  • Boucher LM, Marengère LE, Lu Y, et al. (1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.". Biochem. Biophys. Res. Commun. 233 (3): 592-600. doi:10.1006/bbrc.1997.6509. PMID 9168896. 
  • Song HY, Régnier CH, Kirschning CJ, et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792-6. PMID 9275204. 
  • Force WR, Cheung TC, Ware CF (1998). "Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor.". J. Biol. Chem. 272 (49): 30835-40. PMID 9388227. 
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