TRAF3IP2

From Wikipedia, the free encyclopedia

TRAF3 interacting protein 2

Identifiers

TRAF3IP2; ACT1; C6orf4; C6orf5; C6orf6; CIKS; DKFZP586G0522; MGC3581

External IDs

OMIM: 607043 MGI: 2143599 HomoloGene: 15885

Gene ontology
Molecular Function:	• signal transducer activity • protein binding
Cellular Component:	• cellular_component
Biological Process:	• B cell apoptosis • humoral immune response • intracellular signaling cascade • positive regulation of I-kappaB kinase/NF-kappaB cascade • immunoglobulin secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_147200 (mRNA)
NP_671733 (protein)

NM_134000 (mRNA)
NP_598761 (protein)

Location

Chr 6: 111.98 - 112.03 Mb

Chr 10: 39.3 - 39.34 Mb

Pubmed search

[1]

[2]

TRAF3 interacting protein 2, also known as TRAF3IP2, is a human gene.^[1]

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2.

[edit] Further reading

Morelli C, Magnanini C, Mungall AJ, et al. (2000). "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia.". Gene 252 (1-2): 217–25. PMID 10903453.
Li X, Commane M, Nie H, et al. (2000). "Act1, an NF-kappa B-activating protein.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10489–93. doi:10.1073/pnas.160265197. PMID 10962024.
Leonardi A, Chariot A, Claudio E, et al. (2000). "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10494–9. doi:10.1073/pnas.190245697. PMID 10962033.
Qian Y, Zhao Z, Jiang Z, Li X (2002). "Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9386–91. doi:10.1073/pnas.142294499. PMID 12089335.
Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
Xia YF, Li YD, Li X, Geng JG (2002). "Identification of alternatively spliced Act1 and implications for its roles in oncogenesis.". Biochem. Biophys. Res. Commun. 296 (2): 406–12. PMID 12163033.
Kanamori M, Kai C, Hayashizaki Y, Suzuki H (2003). "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.". FEBS Lett. 532 (1-2): 241–6. PMID 12459498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Mauro C, Vito P, Mellone S, et al. (2003). "Role of the adaptor protein CIKS in the activation of the IKK complex.". Biochem. Biophys. Res. Commun. 309 (1): 84–90. PMID 12943667.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.